The combination of naltrexone and bupropion is not approved for use in children under 18 years of age. Children, teenagers, and young adults who take antidepressants to treat depression or other mental illnesses may be more likely to become suicidal than children, teenagers, and young adults who do not take antidepressants to treat these conditions. A small number of children, teenagers, and young adults (up to 24 years of age) who took antidepressants ('mood elevators') such as bupropion during clinical studies became suicidal (thinking about harming or killing oneself or planning or trying to do so). Do not stop using any medications without first talking to your doctor.This medication contains bupropion, the same active ingredient as some antidepressant medications (Wellbutrin, Aplenzin) and a medication used to help people stop smoking (Zyban). It is important to tell your doctor about all other medications you use, including vitamins and herbs. Not typical for you, you should immediately stop taking varenicline and contact your doctor. If you develop nervousness, agitation, hostility, aggressive behavior, depression, thoughts of suicide, or have other changes in your behavior or thinking that are Also use caution driving or operating machinery until you know how quitting smoking and/or varenicline may affect you. You should limit the consumption of alcohol until you know whether varenicline affects your tolerance for alcohol. Some patients treated with varenicline have experienced decreased tolerance to alcohol, including increased drunkenness, unusual or aggressive behavior, or they had no memory of things that happened. Varenicline may alter the way you react to alcohol.
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